Welcome To
Avican Lab
About Us
Bacterial infections are linked to high human morbidity and death rates and antibiotic-resistant bacteria are becoming a more widespread concern. Aside from their virulence strategies, diverse bacterial pathogens are extremely capable of adapting to stressful host environments. They sense and respond to stressors by re-programming their transcriptome with complex regulatory networks for maintenance of infection. Therefore, bacterial stress responses can be potential targets for novel antimicrobial strategies. We aim to retrieve novel knowledge of bacterial tissue adaptation mechanisms and identify bacterial gene products which can be used as potential antimicrobial targets in combatting bacterial infections.
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Our experimental systems biology approach produces large transcriptomics and genomics data (currently), both from laboratory settings and directly from infected human specimens. We have revealed and analysed gene expression of 32 human pathogens exposed to 11 infection-relevant conditions and collected all data in a searchable database, PATHOgenex constituting an excellent source for applications of systems biology approaches.
Co-PATHOgenex, an interactive and user-friendly web application that enables users to construct networks from gene co-expressions using custom-defined thresholds. The incorporated search functions and visualizations within the tool simplify the usage and facilitate the interpretation of the analysis output. Co-PATHOgenex also includes stress stimulons for various bacterial species, which can help identify gene products not previously associated with a particular stress condition.
